The U.S. Regional Economy, Greenhouse Gas, and Energy (US-REGEN) model is an energy-economy model developed and maintained by EPRI. The model links a detailed electric sector capacity planning and fuels supply model with representations of demand in buildings, transport, and industry. US-REGEN provides a customizable platform for policy analysis, technology assessment, and strategy that is informed by decades of EPRI research on energy modeling and technology analysis. This report provides a high-level introduction to the model and complements the detailed model documentation, peer-reviewed journal articles, and EPRI reports, which are available at https://esca.epri.com/.