There is increasing interest in carbon-free electricity procurement, including procuring and supplying carbon-free energy 24 hours per day, 7 days per week (24/7 CFE) and targeting “emissionality,” the consequential emissions impact of adding clean electricity to a specific grid at a specific time. This analysis uses EPRI’s U.S. Regional Economy, Greenhouse Gas, and Energy (US-REGEN) model to assess potential system effects of CFE procurement and emissionality strategies across a range of conditions. Model results suggest that 24/7 CFE procurement can reduce emissions, but impacts depend on assumptions about policy incentives, regional conditions, and technology availability. The analysis finds that displaced emissions vary dramatically by region and that historical grid emissions factors can diverge significantly from modeled long-run marginal emissions, reflecting the importance of investment responses rather than dispatch alone. Regions with high current emissions intensity do not necessarily offer the highest consequential emissions reductions, and emissionality rank orderings shift depending on whether historical average, short-run marginal, or long-run marginal metrics are used. Forward-looking system modeling is valuable for capturing true consequential impacts of clean energy procurement strategies.