Identifying cost-effective technology pathways that will both comply with prospective zero-CO2 policies and provide adequate reliability is a particularly salient challenge facing electric utilities. Compliance with zero-CO2 policies often implies rapid retirement of firm, dispatchable fossil fuel resources which have historically been the cornerstone of maintaining reliability, and deployment of significant levels of variable renewable energy which requires more coordination among system resources. This presentation describes an analysis using EPRI’s in-house energy system modeling framework, the U.S. Regional Economy, Greenhouse Gas, and Energy Model (US-REGEN), to identify technology pathways to reach zero CO2 in the electric sector by 2035, and Energy Exemplar’s capacity planning and grid operations model, PLEXOS, to calculate common reliability metrics for each scenario’s technology portfolio. This study provides initial insights about potential reliability changes underlying zero-CO2 policy options and identifies several opportunities for future research.