For each of the past ten years, EPRI’s research program on Integrated Energy System Planning (Project Set 178B), in conjunction with member electric companies, has developed different scenarios of potential future technology, regulatory, and market conditions that may exist in the United States in the coming decades, and analyzed how the electric sector might evolve under these scenarios. This presentation, and the accompanying Excel spreadsheet datasets, highlight the analysis and results from our 2022 REGEN Scenarios Analysis Project. In 2022, we analyzed how U.S. electric power generation may evolve through 2035 under a Reference scenario and 14 alternative economic, policy, and market scenarios. Specifically, the scenarios explored the potential impacts of supply chain-related technology disruptions, constraints on building new transmission infrastructure, and optimistic future battery energy storage costs. Each of these potential technology futures were further analyzed across three alternative policy futures, including business-as-usual, a net-zero CO2 electric sector by 2035, and a carbon-free (no offsets) electric sector by 2035. Results focus on comparing future generation portfolios, emissions, system costs, and 2035 operations.